Forces behind N- and C-capping of peptidic helices.

ABSTRACT: Helical peptides are primarily stabilized by intramolecular hydrogen bonds. Particular conformational arrangements, capping motifs, help precisely terminate helices by compensating for disruption of helical H-bonding patterns. This contribution explores if: (i) N-and C-caps are essentially the same; and, (ii) how differences impact their thermodynamic helix stabilities and folding kinetics.

SUBMITTER: Mi T 

PROVIDER: S-EPMC12801117 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature