Dissecting the genetics of human high myopia: a molecular biologic approach.

ABSTRACT:

Purpose

Despite the plethora of experimental myopia animal studies that demonstrate biochemical factor changes in various eye tissues, and limited human studies utilizing pharmacologic agents to thwart axial elongation, we have little knowledge of the basic physiology that drives myopic development. Identifying the implicated genes for myopia susceptibility will provide a fundamental molecular understanding of how myopia occurs and may lead to directed physiologic (ie, pharmacologic, gene therapy) interventions. The purpose of this proposal is to describe the results of positional candidate gene screening of selected genes within the autosomal dominant high-grade myopia-2 locus (MYP2) on chromosome 18p11.31.

Methods

A physical map of a contracted MYP2 interval was compiled,

SUBMITTER: Young TL 

PROVIDER: S-EPMC1280112 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature