Fast Interneuron Dysfunction in Laminar Neural Mass Model Reproduces Alzheimer's Oscillatory Biomarkers.

ABSTRACT: Early-stage AD involves cortical hyperexcitability, progressing to oscillatory slowing and hypoactivity. These changes are linked to parvalbumin-positive ( PV$$ PV $$ ) interneuron dysfunction and neuronal loss driven by amyloid-beta ( Aβ$$ \mathrm{A}\upbeta $$ ) and hyperphosphorylated tau (hp- τ$$ \tau $$ ), though underlying mechanisms remain unclear. To investigate this relationship, we employed a Laminar Neural Mass Model integrating excitatory and inhibitory populations. Synaptic coupling from PV$$ PV $$ interneurons to pyramidal cells was progressively reduced to mimic Aβ$$ \mathrm{A}\upbeta $$ -induced neurotoxicity. Additional parameter variations simulated alternate mechanisms, including hp-tau pathology. Simulated dipole activity was analyzed in the time-frequency domain and com

SUBMITTER: Sanchez-Todo R 

PROVIDER: S-EPMC12801143 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature