Sustained Structural and Functional Deficits in the Porcine Knee Six Months Following Meniscus Destabilization.

ABSTRACT: Osteoarthritis (OA) of the knee is a leading cause of pain and disability. Large animal models that accurately reflect the human OA phenotype are essential for evaluating new therapeutics. This study sought to evaluate a porcine model of knee injury using an enhanced destabilization of the medial meniscus (DMM+) approach in which a 5 mm portion of the medial meniscus anterior (cranial) attachment (cranial medial meniscotibial ligament) was resected. A series of quantitative and semi-quantitative measures of joint-wide structure and function were used to assess joint degeneration at 6 weeks and 6 months postoperatively, including cartilage mechanical testing, subchondral bone analysis, osteochondral and synovial histology and gait analysis. Results showed that early degenerative changes wer

SUBMITTER: Stoeckl BD 

PROVIDER: S-EPMC12801175 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature