Synthesis, Supramolecular Assembly, and Hydrogelation of Poly(amino ester) ABA Triblock Copolymers.

ABSTRACT: Poly(amino esters) derived from N-acylated-1,4-oxazepan-7-ones (OxPs) emerge as promising candidates in the development of new and degradable amphiphiles for hydrogel preparation and delivery formulations. Here, the synthesis of amphiphilic triblock copolymers by ring-opening copolymerization of OxP monomers with various pendant chains is reported. Copolymerization using organocatalysts and a bifunctional initiator afforded neutral P(OxP_Me)-b-P(OxP_Bn)-b-P(OxP_Me) and cationic P(OxP_NH2⁺)-b-P(OxP_Bn)-b-P(OxP_NH2⁺) amphiphilic triblock copolymers with controlled molar masses ranging from 4,600 to 8,500 g/mol and narrow dispersities (Đ ≤ 1.21). A panel of polymers with variou

SUBMITTER: Pascouau C 

PROVIDER: S-EPMC12801195 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature