Redox-Responsive Self-Assembled Amphiphilic Nanosheets from Polyglycerol Sulfate-Lipoic Acid Copolymers for Targeted Cancer Drug Delivery.

ABSTRACT: Targeted drug delivery systems that are stimuli-responsive offer great potential for enhancing the therapeutic activity of drugs, decreasing off-target effects, and improving bioavailability. This proof-of-concept study introduces an amphiphilic drug delivery system (DDS) capable of loading hydrophobic cargo. Elevated glutathione (GSH) levels, characteristic of certain types of cancer cells' microenvironment, degrade the nanostructures and release the cargo. Linear polyglycerol sulfate (LPGS), known for its excellent biocompatibility, is combined with lipoic acid (LA). LA facilitates the formation of cross-linked nanosheet amphiphiles sensitive to reductive conditions. Morphological changes are observed by scanning electron microscopy (SEM), cryogenic transmission electron microscopy (Cryo

SUBMITTER: Page TM 

PROVIDER: S-EPMC12801293 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature