Synthesis and Characterization of Biomimetic Thermoplastic Polyurethanes and Nanocomposites with l-Lysine Diisocyanate.

ABSTRACT: Biomimetic materials are of significant interest in applications such as soft tissue repair, with their ability to replicate morphology and properties of native tissue. This study reports a novel thermoplastic polyurethane (TPU) synthesized with an amino acid-based diisocyanate hard segment. The effects of hard segment percentage on the mechanical, thermal, and hydrophilic properties were assessed. The optimal TPU shows a Young's modulus of 0.19 MPa, a tensile strength of 0.61 MPa, and an elongation at break of 2375%. Incorporating a novel functionalized clay in this TPU gives excellent antibacterial properties, demonstrating efficacy against both Gram-positive and Gram-negative bacterial strains. The addition of this clay also significantly enhances the mechanical properties of the TPU, w

SUBMITTER: Bateman C 

PROVIDER: S-EPMC12801311 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature