Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells.

ABSTRACT: Employing messenger RNA (mRNA) for protein production in the liver or for vaccine purposes is a promising therapeutic approach. However, unlocking mRNA's full therapeutic potential requires systemic delivery platform technology with controllable biodistribution features. Apolipoprotein nanoparticles (aNP) containing monovalent ionizable cationic lipids have been shown to functionally deliver mRNA to myeloid progenitor cells in the bone marrow after intravenous administration. Here, the development of polyvalent ionizable cationic dendrimers is reported for incorporation in aNPs to enable efficient mRNA complexation and functional delivery. A library of dendrimers is first rationally designed with diverse hydrophobic core units, a number of branching units, and functionalized terminal units

SUBMITTER: Trines MM 

PROVIDER: S-EPMC12801360 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature