Characterizing CSF inflammatory proteomics in pediatric post-hemorrhagic hydrocephalus and Anti-NMDAR encephalitis.

ABSTRACT:

Background

Neuroinflammation is a key contributor to pathology in many central nervous system (CNS) diseases. While cerebrospinal fluid (CSF) proteomic studies in adult neurologic conditions have identified insightful inflammatory signatures, fewer studies have been conducted in pediatric diseases. Moreover, past studies primarily employed proteomic approaches that are less suited to detect novel, low-abundance inflammatory mediators that may be critical in pediatric CNS pathophysiology. To address this gap, we applied high-sensitivity, multi-targeted proteomic profiling to characterize the neuroinflammatory signatures across three distinct pediatric neurologic diseases: post-hemorrhagic hydrocephalus (PHH), N-methyl-D-aspartate receptor encephalitis (NMDARE), and brain tumor-assoc

SUBMITTER: Broudy T 

PROVIDER: S-EPMC12801427 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature