Diabetes mellitus and the risk of ovarian cancer: an updated systematic review and meta-analysis of cohort and case-control studies.

ABSTRACT:

Objective

The goal of this study is to evaluate the association between diabetes mellitus and the risk of ovarian cancer development through an updated systematic review and meta-analysis.

Methods

A comprehensive search was conducted across multiple databases from their inception through April 2025, identifying observational studies that provided quantitative risk estimates for the correlation between diabetes mellitus and ovarian cancer. Pooled relative risks and corresponding confidence intervals were determined via random-effects models. Subgroup analyses were performed based on diabetes subtype, study design, age, geographic region, adjustment status and study quality which was evaluated through the Newcastle-Ottawa Scale.

Results

The pooled relative risk (RR) was

SUBMITTER: Ghadirzadeh B 

PROVIDER: S-EPMC12801470 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature