Hypothyroidism as a risk factor for perioperative complications in lumbar spine surgery: a national database study.

ABSTRACT:

Background

Hypothyroidism is a highly prevalent endocrine disorder increasingly recognized as a potential modifier of perioperative risk in orthopedic surgery. Emerging evidence indicates associations between hypothyroidism and adverse perioperative outcomes, including systemic complications and delayed recovery, in orthopedic populations. However, existing analyses remain limited by small sample sizes, lack of surgical subtype stratification, and insufficient focus on lumbar spine surgery (LSS) specifically. To address this gap, we leveraged data from the Nationwide Inpatient Sample (NIS) to clarify the association between hypothyroidism and perioperative complications in patients undergoing LSS.

Methods

A retrospective analysis was performed utilizing the NIS database (201

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12801521 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature