Cognitive dysfunction in type 1 diabetes: role of TREM2 in microglial activation and Aβ pathology.

ABSTRACT:

Background

Cognitive dysfunction associated with type 1 diabetes (T1D) is closely linked to the accumulation of amyloid-beta (Aβ) oligomers. However, the role of microglia and their underlying molecular mechanisms in this process remain unclear. Triggering receptor expressed on myeloid cells 2 (TREM2), a microglial receptor critical for clearing neurotoxic Aβ and maintaining metabolic homeostasis, is dysfunctional in Alzheimer's disease. Here, we investigated TREM2-mediated microglial dysfunction in diabetic neurodegeneration.

Purpose

To investigate the role of TREM2-mediated microglial dysfunction in Aβ clearance and cognitive impairment in T1D.

Basic procedures

A total of 204 male C57BL/6J mice, aged 6-8 weeks, were used in this study. We performed single-nucleus RN

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12801531 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature