Diagnostic significance of cardiac bridging integrator 1 score in hospitalized patients with heart failure with preserved ejection fraction and its assessment of prognostic value for major adverse cardiac events.

ABSTRACT:

Background

Cardiac bridging integrator 1 (cBIN1) is a cardiomyocyte-specific protein critical for excitation-contraction coupling. The cBIN1 score (CS), derived from plasma cBIN1 levels, serves as a non-invasive biomarker reflecting myocardial microstructural integrity and is unaffected by systemic inflammation or BMI.

Methods

A total of 108 HFpEF patients and 108 matched controls were retrospectively included. All subjects underwent clinical evaluation, echocardiography, and biochemical testing. Plasma cBIN1 was measured by ELISA, and CS was calculated. Multivariate logistic regression and ROC analyses were used to assess the diagnostic and prognostic value of CS for HFpEF and major adverse cardiac events (MACE) during 1-year follow-up. A sensitivity analysis was performed

SUBMITTER: Guo X 

PROVIDER: S-EPMC12801533 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature