Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses.

ABSTRACT:

Background

Social isolation and loneliness have emerged as important modifiable risk factors for mental disorders, posing significant public health challenges. However, they have not been comprehensively investigated in relation to multisystemic diseases and their temporal trajectories. We aimed to systematically identify the health outcomes associated with social isolation and loneliness and characterize their disease trajectories and comorbidity networks.

Methods

A total of 466,547 participants (mean age: 56.5 ± 8.1, 54.6% females) with available information on social isolation and loneliness were included from the UK Biobank between 2006 and 2010 and followed up until 2022. Social isolation was measured using a composite score derived from three questions on number in hou

SUBMITTER: Duan T 

PROVIDER: S-EPMC12801555 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature