3D printed, biodegradable, and biocompatible intraperitoneal implants loaded with folic acid-targeted/pH-sensitive/doxorubicin-loaded hydroxyapatite nanoparticles for systemic treatment of metastatic breast cancer.

ABSTRACT: Three-dimensional porous scaffolds with the capability of controlled drug release have gained increasing interest in chemotherapy due to their sustained release of drugs and ability to reduce systemic toxicity. In this study, we advanced this concept by incorporating drug-loaded nanocarriers into 3D-printed scaffolds, creating trackable constructs for medical imaging such as CT-scan. Doxorubicin-loaded/folic acid-targeted pH-sensitive nanohydroxyapatite (Dox@nHA-FA) were synthesized and incorporated into gelatin/polycaprolactone/hydroxyapatite (Gel/PCL/HA) scaffolds via 3D printing. The Gel/PCL/HA(Dox@HA-FA) scaffolds were extensively characterized for drug release, mechanical strength, microstructure, and degradation profile. In vivo, scaffolds with different compositions were implanted i

SUBMITTER: Kefayat A 

PROVIDER: S-EPMC12801578 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature