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Specific atrophy patterns distinguish tau and TDP-43 pathology: a longitudinal MRI ante-mortem study.

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SUBMITTER: Salman Y 

PROVIDER: S-EPMC12801580 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature

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Specific atrophy patterns distinguish tau and TDP-43 pathology: a longitudinal MRI ante-mortem study.

Salman Yasmine Y   Goloubeva Julia J   Huyghe Lara L   Quenon Lisa L   Tomé Sandra O SO   Hanseeuw Bernard B  

Acta neuropathologica communications 20251210 1

TDP-43 pathology frequently co-occurs with Alzheimer’s disease (AD), indicative of Limbic-predominant Age-related TDP-43 Encephalopathy neuropathologic changes (LATE-NC), which is associated with more severe medial temporal lobe (MTL) atrophy and cognitive decline compared to ‘pure’ AD. As both tau and TDP-43 target overlapping MTL structures and are associated with similar clinical manifestations, disentangling their respective contributions to neurodegeneration is essential yet challenging. In  ...[more]

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