Comparative effectiveness of non-pharmacological interventions for knee osteoarthritis: protocol for a Bayesian Network meta-analysis.

ABSTRACT:

Background

Knee osteoarthritis (KOA) is the most common and burdensome form of osteoarthritis worldwide. Although numerous non-pharmacological interventions are recommended in clinical practice, existing evidence remains fragmented and lacks comprehensive comparative evaluation. This study aims to systematically compare the effectiveness of first- and second-line non-pharmacological interventions recommended by the American Academy of Orthopaedic Surgeons (AAOS) for symptomatic KOA using Bayesian network meta-analysis (NMA), which integrates both direct and indirect evidence from randomized controlled trials (RCTs).

Methods

We will conduct a systematic review and Bayesian NMA of randomized trials evaluating non-pharmacological interventions for symptomatic KOA. Eligible inte

SUBMITTER: Pi Z 

PROVIDER: S-EPMC12801583 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature