Heterogeneity of common carotid artery and abdominal aorta: an angle of sphingolipid metabolism in vascular smooth muscle cells.

ABSTRACT:

Background

Atherosclerosis and aortic aneurysms are prevalent aortic disorders. Significantly, atherosclerosis frequently impacts the common carotid artery (CA), whereas aortic aneurysms typically involve the abdominal aorta (AA), indicating possible heterogeneity between CA and AA with an ambiguous underlying mechanism. Sphingolipids, a crucial branch of lipid metabolism, has increasingly garnered attention in vascular diseases by influencing the phenotypic regulation of vascular smooth muscle cells (VSMCs). Nevertheless, whether sphingolipids play a role in the heterogeneity between CA and AA and in disease susceptibility remains uncertain.

Methods and results

Public transcriptomics were employed to clarify the distinctions in contractility and calcification of VSMCs in re

SUBMITTER: Li B 

PROVIDER: S-EPMC12801590 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature