Trigeminal ganglion interferon-γ signaling drives orofacial neuropathic pain in rats.

ABSTRACT:

Background

Chronic neuropathic pain, particularly in the orofacial region, markedly reduces quality of life. Peripheral trigeminal nerve injury activates satellite glial cells (SGCs) in the trigeminal ganglion (TG), which contributes to orofacial neuropathic pain. However, the upstream signal responsible for SGC activation remains unclear. This study investigated the role and cellular sources of interferon gamma (IFN-γ) signaling in the TG following infraorbital nerve injury (IONI) in rats.

Methods

Mechanical sensitivity of the whisker pad skin was assessed after IONI. Changes in IFN-γ levels, IFN-γ receptor expression, and glial fibrillary acidic protein (GFAP; a marker of SGC activation) were examined in the TG by immunohistochemistry. The effects of intra-TG administratio

SUBMITTER: Kobayashi M 

PROVIDER: S-EPMC12801634 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature