Features of DNA methylome in Capsicum spp.

ABSTRACT: DNA methylation is a most heritable epigenetic modification. Being a major vegetable crop, pepper (Capsicum spp.) possesses an over 3 Gb genome populated with TEs. This indicates a rich reservoir of epigenetic regulatory mechanisms. However, this large and complex genome renders the study of DNA methylation unaffordable and technically challenging. In this study, we analyzed DNA methylome in Capsicum spp., with a focus on C. annuum ST-8. We found that the genomes of Capsicum spp. are heavily methylated, particularly in the non-CG contexts. This is true when comparing to wheat, whose genome is over 16 Gb, containing over 80% TEs and repeats. Interestingly, we observed genic non-CG methylation and found that it is likely maintained by the CMTs, instead of RdDM. Overall, there is a negative r

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12801659 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature