NUFIP1 at the crossroads of ribophagy and disease: unveiling therapeutic implications.

ABSTRACT:

Background

Nuclear FMR1-interacting protein 1 (NUFIP1), originally identified as a binding partner of the fragile X mental retardation protein (FMRP), has increasingly been recognized as a pivotal factor in various pathological processes. Its recently elucidated role as a receptor in ribophagy positions it at the intersection of critical cellular pathways, suggesting broad functional significance in human disease pathogenesis. This review synthesizes emerging evidence underscoring the multifaceted involvement of NUFIP1 in key physiological and pathological mechanisms. It regulates fundamental processes such as tumor metabolism, immune responses during sepsis, and recovery from neural injury. Notably, recent findings indicate that impaired NUFIP1 function, particularly within the DN

SUBMITTER: Li Z 

PROVIDER: S-EPMC12801671 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature