Exploratory study on the role of Clonorchis sinensis infection in promoting cholangiocarcinoma progression.

ABSTRACT:

Background

Clonorchiasis, a neglected tropical zoonosis, is caused by chronic infection with Clonorchis sinensis (C. sinensis). This infection can lead to cholangitis, bile duct epithelial hyperplasia, periductal fibrosis, and cholangiocarcinoma (CCA). However, the underlying carcinogenic mechanisms of CCA remain poorly understood, and there is not a well-developed model for C. sinensis CCA.

Methods

A C. sinensis-infected Sprague-Dawley rat model, co-treated with N-nitrosodimethylamine, was established. The study comprised four groups: negative control (NC), C. sinensis infection (CS), N-nitrosodimethylamine induction (NDMA), and combined C. sinensis infection and N-nitrosodimethylamine induction (CSNDMA). Pathological damage to the hepatic ducts was evaluated at 10, 17, and

SUBMITTER: Li S 

PROVIDER: S-EPMC12801685 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature