Recurrent non-suicidal self-injury in depressed youth with mixed features: a 6-month prospective cohort study.

ABSTRACT:

Objective

This study aimed to examine whether mixed features during a current major depressive episode (MDE) are associated with increased risk of non-suicidal self-injury (NSSI) among adolescents and young adults, focusing on both first-onset and recurrent NSSI during a 6-month follow-up period.

Method

A total of 713 individuals aged 13-25 years with current MDE were recruited, including 233 with mixed features. NSSI was assessed at baseline and at 1-, 3-, and 6-month follow-ups. Multiple imputation was used to handle missing data (n = 626). Kaplan-Meier and Nelson-Aalen estimators were applied to visualize time-to-event and cumulative risk curves. Cox regression assessed first-onset NSSI, and Andersen-Gill models estimated the risk of repeated events. Rubin's rules were us

SUBMITTER: Lin K 

PROVIDER: S-EPMC12801809 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature