Abdominal obesity-dependent association between composite upper- and lower-body muscle strength index and incident chronic kidney disease: a nationwide multicenter study.

ABSTRACT:

Background

The relation of composite upper- and lower body-muscle strength index (MSI) with the risk of incident chronic kidney disease (CKD) remains unknown. Our study aims to evaluate the relationship of MSI with new-onset CKD, using longitudinal data from the nationally representative China Health and Retirement Longitudinal Study (CHARLS).

Methods

This multicenter observational study enrolled 4786 community-dwelling adults without baseline chronic kidney disease (CKD) in 2011. Upper and lower body muscle strength were assessed using dynamometer-measured handgrip strength (HGS) and timed performance on 5-repetition chair stand (RCS) test, respectively. A composite muscle strength index (MSI) was derived by combining sex-specific thresholds of HGS (female < 18 kg; male < 2

SUBMITTER: Zhu F 

PROVIDER: S-EPMC12801841 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature