Efficacy and safety of dapsone in adult immune thrombocytopenia: a systematic review and meta-analysis.

ABSTRACT:

Background

Immune thrombocytopenia (ITP) is an autoimmune condition often managed with corticosteroids, intravenous immunoglobulins, or thrombopoietin receptor agonists. In settings where these therapies are inaccessible or contraindicated, dapsone an older antimicrobial agent with immunomodulatory effects has been proposed as an alternative, though its comparative effectiveness and safety profile remain inadequately defined.

Objectives

This study systematically reviews and synthesizes existing data to assess the efficacy and tolerability of dapsone in adult patients with ITP.

Methods

Following PRISMA guidelines, a literature search across PubMed, Embase, and Cochrane databases identified observational studies and interventional trials evaluating dapsone in ITP, inclu

SUBMITTER: Khan I 

PROVIDER: S-EPMC12801843 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature