Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19.

ABSTRACT: Post-Acute Sequelae of COVID-19 (PASC), or "long COVID," describes persistent symptoms following recovery from SARS-CoV-2 infection. Early identification of circulating biomarkers predictive of PASC is critical for prognosis and therapeutic development yet remains poorly defined. To address this gap, we conducted a longitudinal, multi-omics analysis of blood samples from COVID-19 patients (n = 75), stratified by acute disease severity and PASC status. We integrated targeted multiplex assays, untargeted proteomics (LC-MS), and whole blood flow cytometry to define immune and vascular signatures associated with PASC. We found that individuals who went on to develop PASC exhibited a distinct phenotypic signature between 1 and 35 days post-infection, such as significantly elevated plasma Factor

SUBMITTER: Whitcomb LA 

PROVIDER: S-EPMC12801915 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature