Pan-cancer profiling links C1orf50 to DNA repair and immune modulation in ovarian cancer.

ABSTRACT:

Background

C1orf50 encodes a small, evolutionarily conserved protein, the function of which remains unclear. Its significance across various human cancers, particularly its specific role in ovarian cancer within an immunogenomic context, is not yet fully understood. Utilizing The Cancer Genome Atlas and single-cell RNA sequencing (scRNA-seq) public datasets, we conducted a comprehensive profiling of C1orf50 across multiple cancer types, with a particular focus on ovarian cancer, to investigate its associations with copy-number status, genomic instability, tumor programs, and the immune microenvironment.

Results

Across cancer types, copy-number gain or amplification of C1orf50 was most frequent in ovarian cancer and closely tracked with higher messenger RNA levels. Higher C1o

SUBMITTER: Rogachevskaya A 

PROVIDER: S-EPMC12801949 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature