Rumen microbial dysbiosis is associated with productive lifespan decline in dairy cows via metabolic-inflammatory crosstalk.

ABSTRACT:

Background

Gut microbiota has been established as a critical regulator of human longevity, but the mechanistic role of rumen microbiota in dairy cow productive lifespan remains unexplored. This study investigated differences in rumen microbial community structure and metabolic signatures in a longitudinal cohort of dairy cows with divergent productive lifespans, aiming to elucidate the correction and potential regulatory mechanisms governing dairy cow longevity through microbial-host metabolic reprogramming.

Results

Our longitudinal study identified critical trends linked to increasing parity in dairy cows: milk yield and rumen microbiota diversity declined progressively, with microbial communities restructuring to show 37% higher abundance of Alphaproteobacteria and Pseudom

SUBMITTER: Yang P 

PROVIDER: S-EPMC12801975 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature