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APOBEC3B protein expression associates with poor prognosis for breast cancer patients with ER-positive disease.
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ABSTRACT:
SUBMITTER: Schreurs MAC
PROVIDER: S-EPMC12802011 | biostudies-literature | 2025 Dec
REPOSITORIES: biostudies-literature
Publications
APOBEC3B protein expression associates with poor prognosis for breast cancer patients with ER-positive disease.
Breast cancer research : BCR 20251209 1
APOBEC enzymes, including APOBEC3B (A3B), have been linked to recurrent mutational patterns in breast cancers (BC). Currently, there is considerable level of evidence that A3B mRNA expression is associated with poor prognosis in ER-positive BC. Since the clinical relevance of A3B at the protein level has not been well studied, we evaluated A3B protein expression by immunohistochemistry on tumor tissue microarrays. Samples from 646 invasive, non-metastatic primary ER-positive BC patients who did ...[more]