Biochemical characterization of the full-length isoform of soluble adenylyl cyclase.

ABSTRACT: cAMP is a ubiquitous second messenger produced from ATP and involved in many cellular processes. In humans, cAMP is produced from two types of adenylyl cyclases: G protein-regulated transmembrane adenylyl cyclases (ADCY1-9) and bicarbonate- (HCO₃^-) and calcium- (Ca²⁺) regulated soluble adenylyl cyclase (sAC; ADCY10). sAC is molecularly and biochemically distinct from other mammalian nucleotidyl cyclases. In most mammals, sAC arises from a single gene which is predicted to generate multiple isoforms via alternative splicing. In rodents, there are two molecularly identified splice variants: the "full-length" isoform (sAC_fl) and a "truncated" isoform (sAC_t). To date, biochemical and structural characterization of sAC has focused almost ex

SUBMITTER: Ferreira J 

PROVIDER: S-EPMC12802110 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature