Etiology of cirrhosis is associated with risk of hepatic decompensation and hepatocellular carcinoma.

ABSTRACT:

Background

The impact of the changing epidemiology from viral to non-viral etiologies of cirrhosis on the burden of liver-related complications remains unclear.

Methods

We conducted a retrospective cohort study of adult patients with cirrhosis and an index outpatient visit between January and December 2015 at two U.S. health systems. We excluded patients with a history of hepatocellular carcinoma (HCC) or both prevalent ascites and hepatic encephalopathy. Fine-Gray sub-distribution hazard models were used to characterize time-to-incident hepatic decompensation and incident HCC through 2020, with liver transplantation and death as competing events, and multivariable Fine-Gray regression was used to identify associated factors.

Results

We identified 1029 patients (media

SUBMITTER: Ng M 

PROVIDER: S-EPMC12802128 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature