The type II secretion system utilizes GspN for transport of lipoproteins to the <i>Acinetobacter baumannii</i> cell surface.

ABSTRACT: Gram-negative bacteria employ the type II secretion system (T2SS) to not only secrete an array of soluble effectors, such as toxins, to the extracellular space, but also to facilitate the surface localization of enzymes and adhesins that are beneficial to life in different environments. For example, the pullulan-degrading enzyme pullulanase (PulA) from Klebsiella pneumoniae and the recently discovered adhesin InvL from Acinetobacter baumannii are initially expressed with a lipobox containing a signal peptide, resulting in their N-terminal acylation and subsequent surface anchoring after T2SS-mediated export. While outer membrane translocation of both soluble and surface-associated T2SS effectors depends on the T2SS secretin GspD, it is unclear how lipoproteins are accommodate

SUBMITTER: Roberts CS 

PROVIDER: S-EPMC12802150 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature