Hfq orchestrates a robust RNA-RNA interaction network in <i>Acinetobacter baumannii</i>.

ABSTRACT: Across bacteria, RNA binding proteins, such as Hfq, often play a key role in facilitating post-transcriptional regulation by chaperoning interactions between small regulatory RNAs (sRNAs) and their mRNA targets. Acinetobacter baumannii, a problematic gram-negative bacterial pathogen, produces over a hundred sRNAs, of which only a few have experimentally validated mRNA targets. While previous studies have identified hfq as a candidate essential gene in the model multidrug-resistant A. baumannii strain AB5075, the role of Hfq in mediating the regulatory effects of sRNAs remains largely unexplored. Here, we use RIL-seq to identify Hfq-associated sRNA-mRNA interaction partners in strain AB5075. Our results indicate that A. baumannii Hfq coordinates a robust network

SUBMITTER: Intorcia V 

PROVIDER: S-EPMC12802169 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature