Whole-genome sequencing-based pathogen characterization for streptococcal infection directly from positive blood culture samples.

ABSTRACT: Clinical laboratories are increasingly using diagnostic tests directly on positive blood cultures, which may lead to fewer attempts to recover bacterial isolates. Consequently, public health laboratories can benefit from assays that directly process blood culture samples without requiring submission of clinical isolates to determine additional pathogen features not identified by clinical tests, such as vaccine serotype and bacterial genomic relatedness, for surveillance and outbreak response purposes. In partnership with the Minnesota Active Bacterial Core surveillance (ABCs) site, we identified blood culture samples positive for ABCs streptococcal pathogens and characterized them by a direct whole-genome sequencing from blood culture (dWGS) assay. The dWGS results were compared with the r

SUBMITTER: Li Y 

PROVIDER: S-EPMC12802199 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature