Dynamics of B-cell response in MERS-CoV patients and survivors with hybrid immunity.

ABSTRACT: Middle East respiratory syndrome coronavirus (MERS-CoV) causes a highly lethal respiratory infection for which no vaccines or antiviral therapeutics are currently available. Understanding the immune response is critical for designing effective therapeutics. Here, we comprehensively characterized the dynamics of B-cell responses in severely infected MERS-CoV patients and survivors with SARS-CoV-2 exposure history. Infected patients developed robust neutralizing antibody responses within 1 month of illness, with moderate-to-high cross-neutralization activity against SARS-CoV-2. The enhanced neutralization activity coincided with an increased abundance of specific mutated, class-switched IgG clones. Notably, one such clone was detected at moderate prevalence in both patients, and its expansio

SUBMITTER: Al-Khatib HA 

PROVIDER: S-EPMC12802214 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature