Effects of combined high-sensitivity C-reactive protein and residual cholesterol levels on new-onset diabetes: evidence from two prospective cohort studies.

ABSTRACT:

Background

High-sensitivity C-reactive protein (hsCRP) and residual cholesterol (RC) have been pinpointed as potential diabetes risk factors. Nonetheless, the combined impact of these biomarkers on the incidence of diabetes is still unclear. The objective of this analysis is to explore the joint effects of RC and hsCRP on the incidence of new diabetes.

Methods

We analyzed 9,309 individuals in the China Health and Retirement Longitudinal Study (CHARLS) and 4,743 participants in the English Longitudinal Study of Ageing (ELSA), all of whom had no history of diabetes at baseline. To examine the joint effect of RC and hsCRP on diabetes risk, individuals were sorted into four groups based on median RC levels and an hsCRP threshold of 1 mg/L. To comprehensively assess the effects o

SUBMITTER: Shao Y 

PROVIDER: S-EPMC12802226 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature