Dataset Information
HNRNPC reprograms cancer metabolism to drive acquired chemoresistance in colorectal cancer by repressing of Nrf2/SLC7A11-dependent ferroptosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC12802253 | biostudies-literature | 2025 Dec
REPOSITORIES: biostudies-literature
Publications
HNRNPC reprograms cancer metabolism to drive acquired chemoresistance in colorectal cancer by repressing of Nrf2/SLC7A11-dependent ferroptosis.
Cell communication and signaling : CCS 20251210 1
Chemotherapeutic efficacy in colorectal cancer (CRC) is primarily driven by adaptive mechanisms that circumvent therapy-induced ferroptosis. Despite the established role of ROS-mediated lipid peroxidation in initiating ferroptosis, the molecular regulators enabling cancer cells to escape this iron-dependent demise remain elusive. Here, we identify Heterogeneous Nuclear Ribonucleoprotein C (HNRNPC) as a critical orchestrator of chemoresistance in CRC via metabolic reprogramming of ferroptosis ...[more]