Staphylococcal internalization into osteoblasts: a partially conserved mechanism across the genus.

ABSTRACT: Staphylococcus aureus, recognized as a major human pathogen, is associated with severe infections such as bacteremia, endocarditis, skin and soft tissue infections, and bone and joint infections. Virulence mechanisms, including biofilm formation and host cell invasion/internalization, contribute to S. aureus pathogenicity by allowing it to evade the immune system and most antibiotic treatments. S. aureus can be internalized by non-professional phagocytic cells such as fibroblasts, epithelial cells, endothelial cells, and osteoblasts. Its primary internalization pathway is FnBP-fibronectin-α5β1 integrin-dependent. Interestingly, S. pseudintermedius, S. delphini, and S. argenteus can also invade osteoblasts, relying on FnBP-like proteins such as S. pseud

SUBMITTER: Crepin DM 

PROVIDER: S-EPMC12802258 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature