Proteomics mediates the effects of biological aging on the progression of cardio-renal-metabolic comorbidity: a UK biobank cohort study.

ABSTRACT:

Background

Cardio-renal-metabolic (CRM) comorbidity, including cardiovascular disease, chronic kidney disease, and type 2 diabetes mellitus, is prevalent in the population and closely associated with biological aging. However, longitudinal evidence and potential proteomics mediator remain limited.

Methods

We studied 330,177 UK Biobank participants free of CRM diseases at baseline. Biological aging was measured by KDM-BA, PhenoAge, their accelerations, and frailty status, and its effects on CRM progression, including no CRM disease to first, double, and triple CRM diseases, were evaluated using multistate proportional hazards model. In the subpopulation with proteomics data (n = 35,118), 2911 plasma proteins were profiled, and mediation analyses were performed to identify pot

SUBMITTER: Lin Z 

PROVIDER: S-EPMC12802307 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature