Influence of DNA methylation and chromatin accessibility on regulation of gene expression during <i>Trichomonas vaginalis-</i>host cell interaction.

ABSTRACT: Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract, causing infections that range from asymptomatic to highly inflammatory. As an extracellular pathogen, adherence to host epithelial cells is an important step to colonize the human host. Hence, understanding how the process of attachment to host cells is regulated remains an important goal in parasitology research and human health. T. vaginalis-host interaction is regulated by changes in gene expression, but it is still largely unknown how these changes in transcriptional profiles are controlled, as very few transcriptional regulatory elements have been described. Our recent work highlighted the importance of epigenetics in the regulation of transcription, and a specific

SUBMITTER: Munoz D 

PROVIDER: S-EPMC12802312 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature