The acquisition of <i>rmpADC</i> can increase virulence of classical <i>Klebsiella pneumoniae</i> in the absence of other hypervirulence-associated genes.

ABSTRACT: Klebsiella pneumoniae is one of the most common causes of nosocomial infections, and the rise of drug-resistant K. pneumoniae strains is complicating treatment and contributing to a mounting global health crisis. K. pneumoniae has two pathotypes: classical (cKp) and hypervirulent (hvKp). CKp typically causes opportunistic infections in immunocompromised individuals in healthcare settings and often is multi-drug resistant. HvKp can be community-acquired and cause high-mortality infections in immunocompetent individuals. Concerningly, antibiotic-resistant cKp strains with hypervirulence-associated genes and traits have recently emerged. Determining if and how hv-associated genes contribute to increased virulence of cKp strains is essential to addressing this growing thre

SUBMITTER: Salisbury SM 

PROVIDER: S-EPMC12802315 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature