Evaluation of hybrid DIR performance using controlling structures and points of interest in MR-guided adaptive radiotherapy for prostate cancer patients.

ABSTRACT:

Background

MR-guided adaptive radiotherapy (ART) allows for daily plan optimization based on patient-specific anatomy. Accumulated doses, driven by deformable image registration (DIR), of daily fractions can provide cumulative dose metrics and insights into toxicity and tumor control. In prostate ART, inter- and intra-factional deformations, particularly due to bladder and rectum, pose a challenge to accurate DIR generation.

Purpose

To quantify geometric and dosimetric accuracy of a proposed prostate MR-to-MR DIR approach to support MR-guided ART dose accumulation.

Methods

We evaluated DIR accuracy in 25 patients treated with 30 Gy in five fractions on a 1.5 T MR-linac using an adaptive workflow. For all patients, a reference MR was used for planning, with three image

SUBMITTER: Malkov V 

PROVIDER: S-EPMC12802555 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature