TNF Inhibitor-Induced Sarcoidosis-Like Lesions in Inflammatory Bowel Disease.

ABSTRACT:

Background

While tumor necrosis factor (TNF) inhibitors can induce paradoxical reactions, sarcoidosis-like disease has hardly been reported so far. This study aimed to describe the epidemiological, diagnostic and therapeutic features of TNF inhibitor-induced sarcoidosis-like lesions in patients with inflammatory bowel disease.

Methods

We conducted a case series across 59 institutions affiliated with the Groupe d'Etude Therapeutique des Affections Inflammatoires du Tube Digestif. Diagnosis of TNF inhibitor-induced sarcoidosis was based on typical clinical and radiological signs, histological evidence of non-necrotizing granuloma, exclusion of alternative diagnoses, and a timeline consistent with drug exposure. A pharmacovigilance expert reviewed each case to confirm drug caus

SUBMITTER: Chkolnaia Z 

PROVIDER: S-EPMC12802563 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature