Acute Stress Attenuates Hepatic Ischemia-Reperfusion Injury via Hypothalamic CRH Neuron-Induced HPA Axis Activation.

ABSTRACT:

Background

Hepatic ischemia-reperfusion injury (HIRI) is a pathologic process commonly encountered during liver surgery, which seriously threatens patient prognosis. Currently, effective interventions or preventive measures are still lacking. Notably, patients with liver disease commonly experience brief acute stress prior to surgery; however, the impact of acute stress on HIRI remains unclear.

Methods

A 30-min restraint stress was used to simulate acute restraint stress (ARS). Hematoxylin-eosin staining and ELISA were employed to assess HIRI. Immunofluorescence staining and electrophysiology were applied to evaluate neuronal activation. Chemogenetic manipulation was utilized to verify the role of corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricu

SUBMITTER: Lin X 

PROVIDER: S-EPMC12802567 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature