The Efficacy of Combination Therapy With SWTX Capsule and Paroxetine for Depression: A Randomized Controlled Trial.

ABSTRACT:

Background and aims

Depression, a leading global cause of disease burden, often shows limited response and notable adverse reactions to existing antidepressants. Exploring combination therapies is therefore crucial to enhance therapeutic efficacy and improve safety. Consequently, this study aimed to explore the alterations in blood concentration, therapeutic effect, and safety of San Wei Tan Xiang (SWTX) capsule in combination with paroxetine for the treatment of patients suffering from depression.

Methods

Seventy-six patients fulfilling the diagnostic criteria for depression were enrolled in this randomized controlled trial and randomly divided into a Combination Therapy Group (paroxetine plus SWTX capsule) and a Monotherapy Group (paroxetine alone). Paroxetine blood concen

SUBMITTER: Fan Y 

PROVIDER: S-EPMC12802568 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature