Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell transplantation.

ABSTRACT: Research on cell therapy for spinal cord injury has yet to achieve sufficient functional recovery. Previous studies in the field grafted oligodendrocyte progenitors, nonspinal neural stem cells or primary spinal neural progenitors. Here we sought to improve functional outcomes by grafting clinically compatible spinal cord neural stem cells derived from human embryonic stem cells (H9-scNSCs). H9-scNSCs significantly improved functional outcomes on a skilled hand task 9.2-fold (P = 2.5 × 10^-27) in hemisected subjects compared with lesioned controls, achieving a fine object retrieval success of 53.4 ± 19.2%, and 2.9-fold (P = 6.3 × 10^-8) superior to controls in hemicontused subjects. Recovery correlated with rehabilitation effort. Grafts extended up to hundred

SUBMITTER: Sinopoulou E 

PROVIDER: S-EPMC12802577 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature