Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2.

ABSTRACT: The expression of beta interferon genes from humans and mice is under the immediate control of a virus-responsive element (VRE) that terminates 110 bp upstream from the transcriptional start site. Whereas a wealth of information is available for the enhanceosome that is formed on the VRE upon the signals generated by viral infection, early observations indicating the existence of other far-upstream control elements have so far remained without a molecular fundament. Guided by a computational analysis of DNA structures, we could locate three as-yet-unknown transcription factor-binding regions at -0.5, -2, and -3 kb. Our present study delineates the interplay of factors YY1 and YY2 as it occurs at the sites at -3 kb and -2 kb (otherwise called HS1 and HS2), consistent with the idea that the

SUBMITTER: Klar M 

PROVIDER: S-EPMC1280260 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature