Improved functional outcomes and cost benefits of door-to-needle time under 30 min in acute ischemic stroke: an observational study.

ABSTRACT:

Introduction

Intravenous thrombolysis (IVT) is cornerstone of acute ischemic stroke(AIS) recanalization therapy. Clinical guidelines advocate achieving Door-to-Needle (DTN) time of 60 min or less, with recent evidence highlighting clinical advantages of even shorter DTN times. However, economic implications of reducing DTN time are less well-studied. This study aims to assess shorter DTN targets impact on clinical outcomes and healthcare costs.

Methods

This observational cohort study included consecutive patients with AIS treated with IVT in a comprehensive stroke center from January 2017 to December 2023. Patients were stratified by DTN time into 4 groups: ≤ 30, 31-45, 46-60, and >60 min. Multivariate linear and logistic regressions were performed to evaluate impact of DTN

SUBMITTER: Wang JDJ 

PROVIDER: S-EPMC12802697 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature