Association between systolic blood pressure variability and severity of cerebral amyloid angiopathy in incident intracerebral hemorrhage.

ABSTRACT:

Introduction

The role of systolic blood pressure (SBP) variability in the pathogenesis of cerebral amyloid angiopathy (CAA) as an underlying cause of intracerebral hemorrhage (ICH) is unknown. We studied SBP variability before ICH according to CAA severity at autopsy.

Methods

We collected office (primary care or hospital clinic) BP readings during 10 years before first-ever ICH onset in adults who died and had brain research autopsy in the Lothian IntraCerebral Hemorrhage, Pathology, Imaging, and Neurological Outcome (LINCHPIN), prospective, population-based, inception cohort study. A neuropathologist assessed CAA severity using a histopathological rating scale, masked to BP readings. Functional principal component analysis was used to model SBP levels by time before ICH, an

SUBMITTER: Moullaali TJ 

PROVIDER: S-EPMC12802715 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature