Accurate Diagnosis of Clinically Isolated Cardiac Sarcoidosis Using a Novel Unipolar Mapping Guided Endomyocardial Biopsy Technique.

ABSTRACT:

Background

In patients with isolated cardiac sarcoidosis, endomyocardial biopsy is required to confirm the diagnosis. However, endomyocardial biopsy has low sensitivity due to the patchy nature of cardiac inflammation in cardiac sarcoidosis, revealing noncaseating granulomas in <25% of patients.

Case summary

A 38-year-old healthy man developed cardiac arrest while he was exercising. Cardiac sarcoidosis or arrhythmogenic right ventricular cardiomyopathy was suspected based on electrocardiogram, echocardiography, and cardiac magnetic resonance findings. Using unipolar mapping on 3-dimensional electroanatomic mapping, the tip of the biopsy catheter was visualized, allowing targeted tissue sampling from the scar area. Histopathologic analysis confirmed a diagnosis of sarcoidosis

SUBMITTER: Kawata H 

PROVIDER: S-EPMC12802717 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature